Execution Timeout Expired

Hi Everyone, I have the following issue on one of my instances V12SP2:

When saving a Part with a large BOM (~1500 Parts) it takes a while with the red wait indicator is shown. Then Chorme displays a message saying the website is unresponsive and I can click Wait or Leave.

The immediately I get an Innovator Error box saying

Edited with the Error Details

What can cause this error? I thought it was a network / server resource issue, but I don't see this kind of behavior in other hosts with similar hardware configuration

Any help is greatly appreciated!